Swimming exercise improves myelin protein zero level in neuropathic rats along with attenuating neuropathic pain.
Exercise induced myelin protein zero improvement in neuropathic pain rats
CONCLUSIONS: Swimming exercise improves myelin protein zero level in neuropathic rats along with attenuating neuropathic pain. This is a promising approach in improving neuropathological disorders including Charcot-Marie-Tooth and Dejerine-Sottas disease.
Somatosens Mot Res. 2023 Jan 11:1-6. doi: 10.1080/08990220.2022.2158800. Online ahead of print.
PURPOSE: Aerobic exercise including swimming plays a suitable role in improving somatosensory injuries. Neuropathic pain is a debilitating condition that occurs following injury or diseases of somatosensory system. In the present study, we tried to investigate the effect of exercise on myelin protein zero of sciatic nerve injured rats.
MATERIALS AND METHODS: Forty male rats (180-220 g) were divided into five groups (intact, sham, sham + exercise, neuropathy, and neuropathy + exercise). Right Sciatic nerve of anesthetized rats was exposed and loosely ligated (four ligations with 1 mm apart) using catgut chromic sutures to induce neuropathy. After 3 days of recovery, swimming exercise began (20 min/day/5 days a week/4 weeks). Mechanical allodynia and thermal hyperalgesia were detected using Von Frey filaments and plantar test, respectively. Sciatic nerve at the place of injury was dissected out to measure the myelin protein zero by western blot analysis. In the intact and sham groups, sciatic nerve removed at the place similar to injured group.
RESULTS: We found that neuropathy significantly (p < 0.05) reduced paw withdrawal mechanical and thermal thresholds and swimming exercise significantly (p < 0.05) increased paw withdrawal mechanical and thermal thresholds compared to the neuropathy group. Moreover, we found that MPZ level significantly (p < 0.01) decreased in neuropathy group against that in sham group, and exercise prominently (p < 0.05) reversed MPZ level towards control level. CONCLUSIONS: Swimming exercise improves myelin protein zero level in neuropathic rats along with attenuating neuropathic pain. This is a promising approach in improving neuropathological disorders including Charcot-Marie-Tooth and Dejerine-Sottas disease. PMID:36630644 | DOI:10.1080/08990220.2022.2158800 SOURCE: Somatosensory & motor research TAGS: swimming CATEGORY: Research SUBCATEGORY: n/a DATE - PUBLISHED: 2023-01-11T20:18:43Z DATE - DOI: 2023-01-11T20:18:43Z DATE - PUBMED: 2023 Jan 11 DATE OUTPUT MATCHED: True DATE - ADDED: Wed, 11 Jan 2023 06:00:00 -0500 DATE - RETRIEVED: 01/11/23 07:04PM 2023-01-11T19:04:57-05:00 FEATURED IMAGE: Media Uploaded (image/png) IDENTIFIER: pmid:36630644,doi:10.1080/08990220.2022.2158800 PUBMED ID: pubmed:36630644 DOI: 10.1080/08990220.2022.2158800 LINK - PUBMED: https://pubmed.ncbi.nlm.nih.gov/36630644/ LINK - DOI: https://doi.org/10.1080/08990220.2022.2158800 LINK - PUBLISHER: https://www.tandfonline.com/doi/full/10.1080/08990220.2022.2158800 REFERENCES: CMT Treatment Report, Urgent Research, 2023-01-11T19:04:57-05:00, https://www.cmttreatmentreport.com.