SUMMARY:
SARS-CoV-2 vaccination could be a predisposing factor for CMTX1 and trigger a sudden presentation.
TITLE:
X-linked Charcot-Marie-Tooth disease after SARS-CoV-2 vaccination mimicked stroke-like episodes: A case report
DESCRIPTION:
CONCLUSION: SARS-CoV-2 vaccination could be a predisposing factor for CMTX1 and trigger a sudden presentation.
CONTENT:
World J Clin Cases. 2023 Jan 16;11(2):464-471. doi: 10.12998/wjcc.v11.i2.464.
ABSTRACT
BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccinations have been administered worldwide, with occasional reports of associated neurological complications. Specifically, the impact of vaccinations on individuals with X-linked Charcot-Marie-Tooth disease type 1 (CMTX1) is unclear. Patients with CMTX1 can have stroke-like episodes with posterior reversible encephalopathy syndrome on magnetic resonance imaging (MRI), although this is rare.
CASE SUMMARY: A 39-year-old man was admitted with episodic aphasia and dysphagia for 2 d. He received SARS-CoV-2 vaccination 39 d before admission. Physical examination showed pes cavus and reduced tendon reflexes. Brain MRI showed bilateral, symmetrical, restricted diffusion with T2 hyperintensities in the cerebral hemispheres. Nerve conduction studies revealed peripheral nerve damage. He was diagnosed with Charcot-Marie-Tooth disease, and a hemizygous mutation in the GJB1 gene on the X chromosome, known to be pathogenic for CMTX1, was identified. Initially, we suspected transient ischemic attack or demyelinating leukoencephalopathy. We initiated treatment with antithrombotic therapy and immunotherapy. At 1.5 mo after discharge, brain MRI showed complete resolution of lesions, with no recurrence.
CONCLUSION: SARS-CoV-2 vaccination could be a predisposing factor for CMTX1 and trigger a sudden presentation.
PMID:36686343 | PMC:PMC9850968 | DOI:10.12998/wjcc.v11.i2.464
SOURCE:
World journal of clinical cases
TAGS:
SARSCoV2
CATEGORY:
Research
SUBCATEGORY:
n/a
DATE – PUBLISHED:
2023-01-11T13:01:50Z
DATE – DOI: 2023-01-11T13:01:50Z
DATE – PUBMED: 2023 Jan 16
DATE OUTPUT MATCHED: True
DATE – ADDED:
Mon, 23 Jan 2023 06:00:00 -0500
DATE – RETRIEVED:
01/23/23 07:00AM
2023-01-23T07:00:08-05:00
FEATURED IMAGE:
Media Uploaded (image/png)
IDENTIFIER:
pmid:36686343,pmc:PMC9850968,doi:10.12998/wjcc.v11.i2.464
PUBMED ID:
pubmed:36686343
DOI:
10.12998/wjcc.v11.i2.464
LINK – PUBMED:
https://pubmed.ncbi.nlm.nih.gov/36686343/
LINK – DOI:
https://doi.org/10.12998/wjcc.v11.i2.464
LINK – PUBLISHER:
https://www.wjgnet.com/2307-8960/full/v11/i2/464.htm
REFERENCES:
CMT Treatment Report, Urgent Research, 2023-01-23T07:00:08-05:00, https://www.cmttreatmentreport.com.
